Is there a disease that makes us love cats? – Jaap de Roode


Is there a disease
that makes us love cats, and do you have it? Maybe, and it’s more likely than you’d think. We’re talking about toxoplasmosis, a disease caused by toxoplasma gondii. Like all parasites, toxoplasma lives
at the expense of its host, and needs its host to produce offspring. To do that, toxo orchestrates a brain
manipulation scheme involving cats, their rodent prey, and virtually all other birds and mammals, including humans. Documented human infections go as far back
as ancient Egypt. We found samples in mummies. Today, about a third of the world’s
population is infected, and most of them never even know it. In healthy people, symptoms often
don’t show up at all. When they do, they’re mild and flu-like. But those are just the physical symptoms. Toxoplasma also nestles into our brains and meddles with our behavior
behind the scenes. To understand why, let’s take a look
at the parasite’s life cycle. While the parasite can multiply
in practically any host, it can only reproduce sexually
in the intestines of cats. The offspring, called oocysts,
are shed in the cat’s feces. A single cat can shed up to
a hundred million oocysts. If another animal, like a mouse,
accidentally ingests them, they’ll invade the mouse’s tissues
and mature to form tissue cysts. If the mouse gets eaten by a cat, the tissue cysts become active
and release offspring that mate to form new oocysts, completing the cycle. But there’s a problem. A mouse’s natural desire to avoid
a cat makes it tough to close this loop. Toxoplasma has a solution for that. The parasites invade white blood cells
to hitch a ride to the brain where they seem to override the innate
fear of predators. Infected rodents are more reckless
and have slower reaction times. Strangest of all, they’re actually
attracted to feline urine, which probably makes them more likely
to cross paths with a cat and help the parasite
complete its life cycle. How does the parasite pull this off? Although the exact mechanism isn’t known,
toxo appears to increase dopamine, a brain neurotransmitter that is involved
in novelty-seeking behavior. Thus, one idea is that toxo tinkers
with neurotransmitters, the chemical signals
that modulate emotions. The result? Fatal attraction. But mice aren’t the only animals
that end up with these parasites, and that’s where humans,
and all of toxo’s other hosts, come in. We can accidentally ingest oocysts
in contaminated water, or unwashed produce, or from playing in sandboxes, or cleaning out litter boxes. This is behind the common recommendation
that pregnant women not change cat litter. Toxo can cause serious birth defects. We can also get toxo
from eating undercooked meat from other animals that picked up
some oocysts. And it turns out that toxo can mess with
our brains, too. Studies have found connections between
toxo and schizophrenia, biopolar disorder, obsessive compulsive disorder, and aggression. It also slows reactions
and decreases concentration, which may be why one study found
that people involved in traffic accidents were almost three times more likely
to have toxoplasma. So is toxo manipulating our brains
as an evolutionary strategy to get predatory cats to eat us? Or are our brains just similar enough
to a rodent’s that the same neurological tricks that
lure them in catch us in the net, too? And is toxo the reason so many people
love cats and keep them as pets? Well, the jury’s still out on that one. Some recent studies
even contradict the idea. Regardless, toxoplasma has definitely
benefited from humans to become one of the world’s
most successful parasites. It’s not just our willingness to let
cats on our dining room tables or in our beds. Raising livestock
and building cities which attract rodents has provided billions of new hosts, and you and your cat may be two of them.

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